V. B. Grinevich1; S. P. Salikova1; O. V. Bystrova2; A. A. Vlasov1;
A. Osipov2; E. D. Zubrilova1
1S. M. Kirov Military Medical Academy, Saint Petersburg, Russia;
2International Analytical Centre IOC RAS, Moscow, Russia
Aim: To determine a relation between presence of Helicobacter pylori (Hp) in intestine of patients with Congestive Heart Failure (CHF) and Omega-3 Index.
Methods: Totally 42 patients were examined. The main Group 1 con- tained 31 patients with NYHA class III-IV CHF, the comparison Group 2 contained 11 patients with NYHA class I-II CHF. The amount of Hp in intestine’s mucus was determined by measurement of specific 3-hydroxystearic acid (3 h18) value in a blood using algorithm describedearlier. The Omega-3 Index was determined as the percent ratio of omega-3 unsaturated fatty acids (FA) to sum of other FA. All FA values were registered using gas-chromatography mass-spectrometry. Results were presented as average values±standard deviation. Relationships between parameters were determined by calculation of correlation co- efficients (r). Values were considered reliable at significance level P<.05.
Results: Presence of 3h18 was detected in 93.5% of Group 1 patients and in 82% of Group 2 patients. Amount of Hp in intestine’s mucus was 10.9±10.5 cells x105/gram in Group 1 and to 7.04±7.1 in Group 2. After in-patients treatment it has reduced to 5.4±4.3 in Group 1. The lowest Omega-3 Index was determined in Group 1 – 1.59±1, it increased after in-patients treatment up to 2.8±2.4, became compara- ble to one in Group 2 – 3.04±1.3. We determined the reliable negative correlation between Hp amount and Omega-3 Index (r=.37, P<.05). Conclusion: Presence of Hp may influence on pathogenesis of con- gestive heart failure. One of possible mechanisms is Hp’s effect on polyunsaturated FA metabolism.